Publication

[Cell Stem Cell] Scientists combined persistent labeling with time-series single-cell RNA sequencing to build a real-time, quantitative model of in vivo tissue dynamics for murine bone marrow hematopoiesis.

[Nature Communications] Researchers found that Nlrc3, a nucleotide-binding domain leucine-rich repeat containing family gene, was highly expressed in hematopoietic differentiation stages in vivo and vitro and was required in hematopoiesis in zebrafish.

[Leukemia] The authors demonstrated that FLT3 inhibitors increased myeloid maturation with reduced stem/progenitor cell populations in murine fms-like tyrosine kinase 3 (FLT3-ITD) AML.

[Journal Of Hematology & Oncology] A total of 1344 adult patients received an unmanipulated haploidentical transplant at 37 centers from 2012 to 2019 for hematologic malignancy. Investigators compared the outcomes of patients according to the type of graft, using a propensity score analysis.

[NPJ Precision Oncology] Using multiple PLK1-modulated melanoma cell lines, investigators found that PLK1 was involved in the regulation of cell migration, invasion, and epithelial-mesenchymal transition via its kinase activity and NOTCH activation.

[Phytotherapy Research] Scientists shed light on whether and how geniposide (GE) regulated angiopoietin-2 exocytosis. A rat model of adjuvant arthritis was established to evaluate the therapeutic effect of GE especially in synovial angiogenesis.