Publication

[British Journal Of Cancer] Researchers reported that FRAX486, a potent P21-activated kinase 2 (PAK2) inhibitor, facilitated TNBC suppression both in vitro and in vivo by blocking autophagy.

[Signal Transduction And Targeted Therapy] Investigators reported a novel combination of pyrotinib with chrysin and explored its antitumor efficacy and the underlying mechanism in HER2-positive breast cancer.

[Stem Cell Reports] The authors generated isogenic iPSCs carrying the hotspot OPA1 c.2708_2711delTTAG mutation and found that the mutant variant caused defective initial and terminal differentiation and abnormal electrophysiological properties of organoid-derived retinal ganglion cells.

[Science Translational Medicine] Researchers reported that wild-type isocitrate dehydrogenase 1 (IDH1) activated serine biosynthesis by enhancing the expression of phosphoglycerate dehydrogenase and phosphoserine aminotransferase 1.

[Biomaterials Research] Scientists synthesized a polymeric nanocarrier, hyaluronic acid-block-poly (HA-b-PCDA), and explored the use of HA-b-PCDA to simultaneously deliver chemotherapeutic drugs and eradicate breast cancer stem cells.

[Journal of Translational Medicine] Pancreatic tumor samples were collected from patients at Sun Yat-sen University Cancer Center, followed by immunofluorescence analysis.