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Interleukin-30 Subverts Prostate Cancer-Endothelium Crosstalk by Fostering Angiogenesis and Activating Immunoregulatory and Oncogenic Signaling Pathways

[Journal Of Experimental & Clinical Cancer Research] Prostate cancer-endothelial cell interactions were investigated, after coculture, by flow cytometry, transcriptional profiling, western blot, and ELISA assays.

Modeling Post-Implantation Human Development to Yolk Sac Blood Emergence

[Nature] The authors present a genetically inducible stem cell-derived embryoid model of early post-implantation human embryogenesis that captured the reciprocal co-development of embryonic tissue and extra-embryonic endoderm and mesoderm niche with early hematopoiesis.

Mutational Impact of APOBEC3A and APOBEC3B in a Human Cell Line and Comparisons to Breast Cancer

[PLOS Genetics] Researchers reported the development of a selectable system to quantify genome mutation and demonstrated its utility by comparing the mutagenic activities of three leading candidates—APOBEC3A, APOBEC3B, and APOBEC3H.

Ketogenic Diet Does Not Promote Triple-Negative and Luminal Mammary Tumor Growth and Metastasis in Experimental Mice

[Clinical & Experimental Metastasis] Investigators assessed the impact of a Ketogenic diets on growth and metastasis of triple negative murine 4T1 mammary tumors, and on the progression of luminal breast tumors in an autochthonous MMTV-PyMT mouse model.

GDF15 Linked to Maternal Risk of Nausea and Vomiting During Pregnancy

[Nature] Using mass spectrometry to detect a naturally-labelled GDF15 variant researchers demonstrated that the vast majority of GDF15 in the maternal plasma was derived from the feto-placental unit.

Umbilical Cord Mesenchymal Stromal Cells in Serum-Free Defined Medium Display an Improved Safety Profile

[Stem Cell Research & Therapy] Performed a comprehensive investigation of the toxicity, immunogenicity and biodistribution of intraperitoneally umbilical cord MSCs derived using serum-free, xeno-free, and chemically defined media.

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