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Interleukin-30 Subverts Prostate Cancer-Endothelium Crosstalk by Fostering Angiogenesis and Activating Immunoregulatory and Oncogenic Signaling Pathways
[Journal Of Experimental & Clinical Cancer Research] Prostate cancer-endothelial cell interactions were investigated, after coculture, by flow cytometry, transcriptional profiling, western blot, and ELISA assays.
ESC & iPSC News
Modeling Post-Implantation Human Development to Yolk Sac Blood Emergence
[Nature] The authors present a genetically inducible stem cell-derived embryoid model of early post-implantation human embryogenesis that captured the reciprocal co-development of embryonic tissue and extra-embryonic endoderm and mesoderm niche with early hematopoiesis.
Mammary Cell News
Mutational Impact of APOBEC3A and APOBEC3B in a Human Cell Line and Comparisons to Breast Cancer
[PLOS Genetics] Researchers reported the development of a selectable system to quantify genome mutation and demonstrated its utility by comparing the mutagenic activities of three leading candidates—APOBEC3A, APOBEC3B, and APOBEC3H.
Mammary Cell News
Ketogenic Diet Does Not Promote Triple-Negative and Luminal Mammary Tumor Growth and Metastasis in Experimental Mice
[Clinical & Experimental Metastasis] Investigators assessed the impact of a Ketogenic diets on growth and metastasis of triple negative murine 4T1 mammary tumors, and on the progression of luminal breast tumors in an autochthonous MMTV-PyMT mouse model.
Newsletters
GDF15 Linked to Maternal Risk of Nausea and Vomiting During Pregnancy
[Nature] Using mass spectrometry to detect a naturally-labelled GDF15 variant researchers demonstrated that the vast majority of GDF15 in the maternal plasma was derived from the feto-placental unit.
Newsletters
Umbilical Cord Mesenchymal Stromal Cells in Serum-Free Defined Medium Display an Improved Safety Profile
[Stem Cell Research & Therapy] Performed a comprehensive investigation of the toxicity, immunogenicity and biodistribution of intraperitoneally umbilical cord MSCs derived using serum-free, xeno-free, and chemically defined media.