Publication

[Neurochemical Research] NSCs were induced by oxygen-glucose deprivation/reoxygenation for constructing cerebral ischemic stroke cell model.

[Nature Biomedical Engineering] The authors reported an lipid nanoparticle-screening method for the optimization of the type of helper lipid and of lipid-component ratios to enhance the delivery of tumor-antigen-encoding mRNA to dendritic cells and their immune-activation profile towards enhanced antitumor activity.

[Journal of Cell Biology] Scientists showed that B lymphoid tyrosine kinase (BLK) positively regulated TLR/IL-1R–mediated inflammatory response. BLK-deficient mice produced less inflammatory cytokines and were more resistant to death upon IL-1β challenge.

[Cancer Immunology Research] Using a mouse model of ovarian cancer, researchers demonstrated the oncolytic effect and immune-modulatory capacities of CARG-2020.

[Food & Function] Researchers assessed the anti-angiogenic activities of the main circulating isoflavone metabolites and compared them with their corresponding free forms at physiological concentrations. The effects of the conjugated vs. free forms on tubulogenesis, cell migration, and VEGF-induced signaling were investigated in primary human aortic endothelial cells.

[Cancer Biology & Therapy] The effect of exosomes on the angiogenesis of human umbilical vein endothelial cells was assessed using cell counting kit-8, transwell, and tube formation assays. The interaction between miR-1247-3p and forkhead box protein O1 (FOXO1) was studied using luciferase reporter and RNA pull-down assays.