Publication

[Proceedings of The National Academy of Sciences of The United States of America] Researchers showed that brain insulin resistance epigenetically caused zDHHC7 overexpression and induced aberrant S-palmitoylation of proteins regulating synaptic function and amyloid-β metabolism.

[Proceedings of The National Academy of Sciences of The United States of America] Scientists found that cortical-like neurons derived from iPSC lines carrying the hexanucleotide repeat expansion in the C9ORF72 gene, a common genetic cause of frontotemporal dementia (FTD)/ALS, displayed a diminished activation of CREB, resulting in decreased dendritic and synaptic health.

[Nature] Researchers established a mouse model enabling simultaneous genetic access to the brain’s dopamine and 5-hydroxytryptamine neurons.

[Cell Reports] The authors developed a panel of isogenic iPSC lines carrying MAPT splice-site mutations, S305S, S305I, or S305N, derived from four different donors.

[Nature Communications] Researchers profiled 412,132 nuclei from the forebrains of wild-type and MYT1L-deficient mice at three developmental stages: E14 at the peak of neurogenesis, P1 when cortical neurons have been born, and P21 when neurons are maturing, to examine the role of MYT1L levels on neuronal development.

[Nature] Using multi-modal transcriptomic analyses, investigators identified molecularly distinct sympathetic populations in the celiac–superior mesenteric ganglia.