Publication

[Circulation] Researchers deleted a single allele of mitochondrial ribosomal protein S5 in mice and used left anterior descending coronary artery ligation surgery to induce myocardial damage in these animals.

[Journal Of Cachexia Sarcopenia And Muscle] Evidence of activation of the necroptotic axis was examined in dystrophic tissues from Golden retriever muscular dystrophy dogs and R-DMDdel52 rats.

[eLife] Investigators determined that the rare mitofusin (MFN) 2 R400Q mutation was 15–20× over-represented in clinical cardiomyopathy, whereas this specific mutation was not reported as a cause of MFN2 mutant-induced peripheral neuropathy, Charcot–Marie–Tooth disease type 2A.

[Nature Communications] The authors described and characterized the cardiomyocyte specific lncRNA Sweetheart RNA, an approximately 10 kb long transcript divergently expressed from the cardiac core transcription factor coding gene Nkx2-5.

[Applied Physiology Nutrition And Metabolism] The authors determined the effect of supplemental folic acid in utero and throughout suckling on muscle size, function, and metabolism in male and female CD-1 mouse offspring.

[APL Bioengineering] Investigators performed analyses of whole-transcriptome microarray data from mouse vascular smooth muscle cells (VSMCs) cultured on stiff hydrogels simulating arterial pathology that identified 623 genes that were significantly and differentially expressed relative to expression in VSMCs cultured on soft hydrogels.