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Immunology of Infectious Disease News
CMV Reactivation and CMV-Specific Cell-Mediated Immunity After Chimeric Antigen Receptor T Cell Therapy
[Clinical Infectious Diseases] Investigators prospectively enrolled 72 adult cytomegalovirus (CMV)-seropositive CD19-, CD20-, or BCMA-targeted chimeric antigen receptor-modified T cell immunotherapy (CARTx)-recipients and tested plasma for CMV pre- and weekly up to twelve weeks post-CARTx.
Hepatic Cell News
3D Multi-Cell-Type Liver Organoids: A New Model of Non-alcoholic Fatty Liver Disease for Drug Safety Assessments
[Toxicology In Vitro] Researchers generated three-dimensional multi-cell-type liver organoids from HepaRG cells, primary human macrophages, and hepatic-stellate-cell-derived LX-2 cells.
Hepatic Cell News
A Multicellular Liver Organoid Model for Investigating Hepatitis C Virus Infection and Non-alcoholic Fatty Liver Disease Progression
[Hepatology] Investigators presented a novel, multicellular liver organoid model using a co-culture system of macrophages and liver organoids differentiated from the same human pluripotent stem cells.
Mesenchymal Cell News
Immunobiology of Foreign Body Response to Composite PLACL/Gelatin Electrospun Nanofiber Meshes with Mesenchymal Stem/Stromal Cells in a Mouse Model: Implications in Pelvic Floor Tissue...
[Biomaterials Advances] Researchers proposed a tissue engineering strategy using uterine endometrium-derived mesenchymal stem/stromal cells (eMSC) delivered with degradable poly L-lactic acid-co-poly ε-caprolactone (PLACL) and evaluated the immunomodulatory mechanism at the material interfaces.
Extracellular Matrix News
Meniscus-Inspired Self-Lubricating and Friction-Responsive Hydrogels for Protecting Articular Cartilage and Improving Exercise
[ACS Nano] Inspired by the components and functions of the meniscus, scientists developed a self-lubricating and friction-responsive hydrogel that contains nanoliposomes loaded with diclofenac sodium and Kartogenin for anti-inflammation and cartilage regeneration.
Cell Therapy News
Fusogenic Coiled-Coil Peptides Enhance Lipid Nanoparticle-Mediated mRNA Delivery upon Intramyocardial Administration
[ACS Nano] Scientists modified mRNA-lipid nanoparticles with the fusogenic coiled-coil peptides and demonstrated efficient mRNA delivery to difficult-to-transfect induced pluripotent stem-cell-derived cardiomyocytes.