Publication

[Cell Reports] Investigators detected an upregulation of the neuronal axon guidance molecule Netrin-1 in PDAC liver metastases that signals through its dependence receptor, uncoordinated-5b, to facilitate metastasis in vitro and in vivo.

[Scientific Data] In order to better understand chondrogenic differentiation, especially the commitment phase, investigators performed transcriptional profiling of MSC differentiation into chondrocytes from early timepoints starting 15 minutes after induction to 16 hours and fully differentiated chondrocytes at 21 days in triplicates.

[Acta Pharmacologica Sinica] Scientists investigated the changes in thrombospondin-1 (THBS1) expression and its pathological role in the dysfunction of mesenteric artery endothelial cells induced by a high-salt diet.

[Journal Of Immunology] Researchers reported that H2O2 treatment increased expression of E-selectin but decreased expression of the endothelial transcription factor ETS-related gene (ERG) in HUVECs in a dose- and time-dependent manner.

[Peerj Life & Environment] Investigators elucidated the role of the lncRNA LEF1-AS1 in the development of venous malformations and examine the interaction among LEF1-AS1, miR-489-3p, and S100A11 in HUVEC cells.

[Annals Of Anatomy-Anatomischer Anzeiger] Researchers found that the knockdown of MDM2 can attenuate vascular endothelial dysfunction in hypertension, which may be achieved by inhibiting the activation of Notch1 and NLRP3 inflammasome.