Publication

[Emerging Microbes & Infections] Investigators reported the specific neutralizing antibodies 13H7 and 9G11, which targeted the N-terminal domain and receptor-binding domain of the SARS-CoV-2, respectively.

[eLife] Scientists reported that negative clinical outcomes in severely ill patients were associated with divergent RNA transcriptome profiles in peripheral immune cells compared with mild cases during the first weeks after disease onset.

[Scientific Reports] Scientists examined neural stem cell changes via mRNA sequencing in an in vitro Transwell co-culture model. They then explored cell interaction mechanisms using proliferation assays, differentiation assays, and neuron complexity analysis.

[Nature] The authors quantified dynamics of long-term stem cell engraftment, the authors sequenced genomes from 2,824 single-cell-derived hematopoietic colonies of ten donor–recipient pairs taken 9–31 years after HLA-matched sibling HCT3.

[Neuro-Oncology] Hybridoma cells were generated by immunizing BALB/c mice with EVA1-Fc fusion protein. The reactivity of the supernatant from these hybridoma cells was examined using EVA1-overexpressing cells and glioblastoma-initiating cells. Candidate antibodies were further selected using Biacore surface plasmon resonance analysis and two cytotoxicity assays, antibody-dependent cell cytotoxicity and complement-dependent cytotoxicity

[Nature] Investigators provide the mechanistic explanation for this in a requirement for mutant RAS to specifically transform committed progenitors of the myelomonocytic lineage harboring previously acquired driver mutations, showing that advanced leukemic clones can originate from a different cell type in the hematopoietic hierarchy than ancestral clones.