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YAP1 Inhibits RSL3-Induced Castration-Resistant Prostate Cancer Cell Ferroptosis by Driving Glutamine Uptake and Metabolism to GSH
[Molecular And Cellular Biochemistry] In vitro CRPC cell lines were used to determine the effect of YAP1 on glutamine uptake and metabolism to glutathione and RSL3-induced ferroptosis.
Newsletters
Targeting the Fibroblast Growth Factor Pathway in Molecular Subtypes of Castration-Resistant Prostate Cancer
[The Prostate] In vitro/ex vivo analysis of erdafitinib and CH5183284 demonstrated robust and moderate growth suppression of androgen receptor-positive CRPC, respectively.
Newsletters
Fatty Acid Binding Protein 5 Regulates Docetaxel Sensitivity in Taxane-Resistant Prostate Cancer Cells
[PLOS One] Employing taxane-resistant DU145-TXR cells and a combination of cytotoxicity, apoptosis, and cell cycle assays, scientists' findings demonstrated that fatty acid binding protein 5 knockdown sensitized the cells to docetaxel.
Newsletters
Anti-Proliferative Effect of Cannabidiol in Prostate Cancer Cell PC3 Is Mediated by Apoptotic Cell Death, NFκB Activation, Increased Oxidative Stress, and Lower Reduced Glutathione...
[PLOS One] The authors found that cannabidiol decreased prostate cancer cell viability up to 37.25% and induced apoptotic cell death in a time and dose-dependent manner.
Neural Cell News
Notch1 Cortical Signaling Regulates Epithelial Architecture and Cell–Cell Adhesion
[Journal of Cell Biology] Investigators employed a 3D model of a human ductal epithelium to reveal tissue morphogenic defects result from loss of Notch1, but not Notch1 transcriptional signaling.
Mesenchymal Cell News
An Engineered Periosteum for Efficient Delivery of rhBMP-2 and Mesenchymal Progenitor Cells during Bone Regeneration
[npj Regenerative Medicine] Researchers developed a biocompatible, 3D polycaprolactone melt electro-written membrane to act as a mimetic periosteum.