Publication

[Science Advances] The authors reported a series of miRNA-based Lin28A-miRNA proteolysis-targeting chimeras designed to efficiently degrade Lin28A through a ubiquitin-proteasome–dependent mechanism, resulting in up-regulation of mature let-7 family.

[Science Advances] Investigators reported that long-chain acyl-CoA synthase 6 (ACSL6) was highly expressed in liver cancer and correlated with poor prognosis.

[Science Translational Medicine] Using high-dose-rate brachytherapy, the authors treated mice bearing syngeneic tumors with a single fraction of heterogeneous radiation therapy at a dose ranging from 2 to 30 gray.

[Scientific Reports] The authors explored the anti-rosacea effects of adipose tissue extracts in human cathelicidin peptide induced rosacea mice and capsaicin-stimulated HaCaT keratinocytes.

[iScience] Scientists explored the role and potential mechanism of regorafenib in melanoma, and discovered that regorafenib significantly inhibited tumor growth in vivo.

[Experimental & Molecular Medicine] Scientists observed a direct correlation between ferritin, comprising heavy (FTH1) expression and cell viability and clonogenicity in KRAS-mutant PDAC cell lines as well as with in vivo tumor growth through the control of proline metabolism.