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Knockdown of LINC00702 Inhibits the Growth and Induces Apoptosis of Breast Cancer through the Wnt/β-Catenin Pathway

[Heliyon] Researchers elucidated the role of LINC00702, a long non-coding RNA, in breast cancer (BC) with bioinformatic and transcriptomic methods. Additionally, they evaluated the impact of LINC00702 knockdown on BC progression..

Human Umbilical Cord-Derived Mesenchymal Stem Cells (hUC-MSCs) Alleviate Excessive Autophagy of Ovarian Granular Cells Through VEGFA/PI3K/AKT/mTOR Pathway in Premature Ovarian Failure Rat Model

[Journal Of Ovarian Research] The ovarian function was evaluated by ovarian morphology, histology, estrous cycle, hormone levels, and fertility ability to investigate the effect of human umbilical cord-MSCs on the premature ovarian failure rats model.

Human Umbilical Cord-Derived Mesenchymal Stem Cells Ameliorate Perioperative Neurocognitive Disorder by Inhibiting Inflammatory Responses and Activating BDNF/TrkB/CREB Signaling Pathway in Aged Mice

[Current Stem Cell Research & Therapy] Human umbilical cord-MSCs were isolated from an infant umbilical cord and identified using flow cytometry and differentiation assays. Scientists established PND model by undergoing aseptic laparotomy under isoflurane anesthesia maintaining spontaneous ventilation in 18-month-old male C57BL/6 mice.

Cerium Oxide Nanoparticles-Carrying Human Umbilical Cord Mesenchymal Stem Cells Counteract Oxidative Damage and Facilitate Tendon Regeneration

[Journal Of Nanobiotechnology] Researchers synthesized polyethylene glycol-packed CeONPs (PEG-CeONPs), which were loaded into the human umbilical cord MSCs to counteract oxidative damage.

Oxamate Enhances the Efficacy of CAR-T Therapy Against Glioblastoma via Suppressing Ectonucleotidases and CCR8 Lactylation

[Journal Of Experimental & Clinical Cancer Research] Immunocyte subpopulations and molecular characteristics were analyzed in the orthotopic xenografts of nude mice using flow cytometry assay and immunohistochemical staining after oxamate, a lactate dehydrogenase A inhibitor, and control T or CAR-T cells injection alone or in combination.

Control of the Antitumour Activity and Specificity of CAR T Cells via Organic Adapters Covalently Tethering the CAR to Tumour Cells

[Nature Biomedical Engineering] Scientists showed that the tumor-targeting specificity and activity of T cells with a CAR consisting of an antibody with a lysine residue that catalytically formed a reversible covalent bond with a 1,3-diketone hapten can be regulated by the concentration of a small-molecule adapter.

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