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Human Pluripotent Stem Cell-Derived Inner Ear Organoids Recapitulate Otic Development In Vitro

[Development] The authors provided the first direct comparisons of the early human embryonic otocyst and fetal sensory organs with human inner ear organoids.

Impaired Immunosuppressive Effect of Bone Marrow Mesenchymal Stem Cell-Derived Exosomes on T Cells in Aplastic Anemia

[Stem Cell Research & Therapy] CD3 + T cells were collected and cocultured with aplastic anemia-exosomes and exosomes derived from HD-MSC.

Tex10 Interacts With STAT3 to Regulate Hepatocellular Carcinoma Growth and Metastasis

[Molecular Carcinogenesis] The expression of testis expression 10 (Tex10) in the HCC cell line and tissue microarray was determined by Western blot and immunohistochemistry, respectively.

EYA4 Promotes Breast Cancer Progression and Metastasis through Its Role in Replication Stress Avoidance

[Molecular Cancer] Researchers found that the over-expression of Eyes Absent (EYA) homolog 4 in breast tissue led to an aggressive and invasive breast cancer phenotype, while the inhibition of EYA4 reduced tumorigenic properties of breast cancer cells in vitro and in vivo.

Stroma-Mediated Breast Cancer Cell Proliferation Indirectly Drives Chemoresistance by Accelerating Tumor Recovery between Chemotherapy Cycles

[Cancer Research] The authors explored whether the direct reduction of therapy sensitivity induced by stroma-produced paracrine factors contributed to the link between stroma and poor responses to chemotherapies.

Spatiotemporal Modeling of Chemoresistance Evolution in Breast Tumors Uncovers Dependencies on SLC38A7 and SLC46A1

[Cell Reports] Investigators modeled the spatiotemporal changes promoting chemotherapy resistance in breast cancer.

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