Publication

[Nature Communications] Based on house dust mite-induced mice asthma models and human samples, the authors applied flow cytometry, parabiosis, in vivo imaging, and adoptive transplantation to confirm the persistence, migration, and function of CD45+lineage–CD90.2+NK1.1–NKp46–ST2–KLRG1+IL-17RB+ memory-like ILC2s.

[Journal of Allergy and Clinical Immunology] Scientists utilized a tetracycline-inducible system to express IL-33 in the esophagus by generating two transgenic mice.

[EMBO Journal] Investigators performed single-cell RNA transcriptomics on endometrial stromal cells and decidual stromal cells and found that cell senescence during decidualization was accompanied by increased levels of the branched-chain amino acid transporter SLC3A2.

[Proceedings of The National Academy of Sciences of The United States of America] Using single-cell RNA-Seq in a mouse model, researchers determined the transcriptomic profiles and functions of different macrophages within endometriosis lesions and in the peritoneal cavity.

[Proceedings of The National Academy of Sciences of The United States of America] In order to determine the type of cells in which cGAS activation drives autoinflammation, the authors generated conditional cGAS knockout mice on the three prime repair exonuclease 1 (TREX1)-/- background.

[Journal for ImmunoTherapy of Cancer] Single-cell sequencing and flow cytometry analysis showed that tumor tissues from endosialin knockout mice had increased CD8+ T cell infiltration.