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Aflatoxin M1 Decreases the Expression of Genes Encoding Tight Junction Proteins and Influences the Intestinal Epithelial Integrity

[Mycotoxin Research] Scientists evaluated the acute cytotoxic effects of aflatoxin M1 (AFM1) on intestinal Caco-2 cells. Initially, they checked the morphology and viability of Caco-2 cells after treatment with different concentrations of AFM1 for different time intervals

Exploring the Therapeutic Potential of Fe3O4@Glu-Oleuropein Nanoparticles in Targeting KRAS Pathway-Regulating lncRNAs in Colorectal Cancer Cells

[Biological Trace Element Research] Researchers employed iron oxide nanoparticles coated with glucose and conjugated with Oleuropein (Fe3O4@Glu-Oleuropein NPs) to evaluate their impact on candidate lncRNAs associated with KRAS pathway deregulation.

Inversely Engineered Biomimetic Flexible Network Scaffolds for Soft Tissue Regeneration

[Science Advances] The authors demonstrated a class of rationally designed flexible network scaffolds that could precisely replicate nonlinear mechanical responses of soft tissues and enhance tissue regeneration via reduced graft-host mechanical mismatch.

Tracing Immune Cells Around Biomaterials with Spatial Anchors during Large-Scale Wound Regeneration

[Nature Communications] Researchers presented a method for large-area wound regeneration using biodegradable aligned extracellular matrix scaffolds, and showed that the implantation of these scaffolds accelerated wound coverage and enhanced hair follicle neogenesis.

Human Osteoarthritic Articular Cartilage Stem Cells Suppress Osteoclasts and Improve Subchondral Bone Remodeling in Experimental Knee Osteoarthritis Partially by Releasing TNFAIP3

[Stem Cell Research & Therapy] Bioinformatic and functional analysis showed that articular cartilage stem cells suppressed osteoarthritic osteoclasts formation, and inflammatory joint microenvironment augmented the inhibitory effects.

Promoting Stem Cell Mechanosensing and Osteogenesis by Hybrid Soft Fibers

[ACS Applied Materials & Interfaces] Investigators prepared soft fibrous scaffolds modified with Zn-MOF-74 nanoparticles via electrostatic spinning, which permitted remodeling under cellular adhesive force, optimizing the mechanical cues in the microenvironment to support cell adhesion and mechanosensing.

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