Publication

[Molecular Therapy] The prophylactic use of a protein arginine methyltransferase 1 (PRMT1) inhibitor significantly prevented chronic graft-versus-host disease in mice by reducing the percentage of Th17 cells, germinal center B cells, and plasma cells.

[Cell Reports Medicine] Researchers reported that anti-obesogenic and anti-inflammatory functions of adenosine A2A receptor significantly restrain HCC development. Adora2a deletion in mice triggered obesity, non-alcoholic steatohepatitis (NASH), and systemic inflammation.

[Cell Reports Medicine] Investigators found that combining an inhibitor of liver ATP citrate lyase (ACLY), bempedoic acid, and the GLP-1R agonist liraglutide reduced liver steatosis, hepatocellular ballooning, and hepatic fibrosis in a mouse model of nonalcoholic steatohepatitis.

[Molecular Therapy] Investigators found that 18S rRNA m6A modification and its methyltransferase METTL5 were aberrantly upregulated in intrahepatic cholangiocarcinoma and associated with poorer survival.

[eLife] Investigators reported a fundamental and unexpected role of neutrophils as the predominant phagocyte responsible for the clearance of apoptotic hepatic cells in the steady state.

[Cell Biology And Toxicology] The authors uncovered that the potent non-coding RNA Tug1, which was related to metabolic enzymes, regulated hepatocytes steatosis induced by sodium palmitate via miR-1934-3p absorbing.