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Development and Characterization of Biological Sutures Made of Cell-Assembled Extracellular Matrix

[Biofabrication] In vivo carotid anastomoses realized in sheep demonstrated that the biological sutures were compatible with standard vascular surgery techniques.

LZTR1 Deficiency Exerts High Metastatic Potential by Enhancing Sensitivity to EMT Induction and Controlling KLHL12-Mediated Collagen Secretion

[Cell Death & Disease] Scientists found that leucine zipper-like transcriptional regulator 1 (LZTR1) deficiency significantly increased lung metastasis, and promoted ECM deposition around metastatic tumors.

Generation of Human Endometrial Assembloids with a Luminal Epithelium Using Air–Liquid Interface Culture Methods

[Advanced Science] A novel endometrial assembloid model was developed by combining endometrial epithelial cells and stromal cells, and using an improved matrix and air–liquid interface culture method.

The Mechano-Chemical Circuit Drives Skin Organoid Self-Organization

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Cell behavior videos showed that the morphological transformation from multiple spheroidal units with morphogenesis competence to planar skin was characterized by two abrupt cell motility–increasing events before calming down.

A Pillar and Perfusion Plate Platform for Robust Human Organoid Culture and Analysis

[Advanced Healthcare Materials] The authors engineered “microarray three-dimensional bioprinting” technology and associated pillar and perfusion plates for human organoid culture and analysis.

Druggable Redox Pathways against Mycobacterium abscessus in Cystic Fibrosis Patient-Derived Airway Organoids

[PLOS Pathogens] Investigators used human airway organoids microinjected with smooth or rough Mycobacterium abscessus to evaluate bacteria fitness, host responses to infection, and new treatment efficacy.

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