Publication

[Diabetes Care] To test whether blocking innate immaune cells modulated progression of the disease, we randomly assigned 273 individuals with stage 1 T1D to treatment with hydroxychloroquine or placebo and assessed whether hydroxychloroquine treatment delayed or prevented progression to stage 2 T1D

[NPJ Regenerative Medicine] Scientists developed a bone morphogenetic protein-2 (BMP2)-hydrogel treatment via a transphyseal bone wash and subsequential injection of BMP2-loaded hydrogel.

[Nature Immunology] Researchers found that NFAT5, an NFAT family transcription factor that lacks an AP-1 docking site, was highly expressed in exhausted CD8+ T cells in the context of chronic infections and tumors but was selectively required in tumor-induced CD8M+ T cell exhaustion.

[Signal Transduction and Targeted Therapy] Researchers generated mice with liver-specific knockout of mineral dust-induced gene (MDIG) and applied partial hepatectomy or carbon tetrachloride mouse models to investigate the biological contribution of MDIG in liver regeneration.

[Journal of Experimental & Clinical Cancer Research] Circular RNA hsa_circ_0001681 was identified by circular RNA sequencing from 19 pairs of intrahepatic cholangiocarcinoma and adjacent tissue samples.

[Cell & Bioscience] Due to the high similarity with humans, the authors generated leptin-deficient pigs to investigate the mechanisms and clinical trials of obesity and non-alcoholic fatty liver disease (NAFLD) caused by leptin.