Publication

[Blood Advances] Investigators demonstrated that NEUROBEACHIN and related BEACH-domain containing proteins, including LRBA, NBEAL1 and LYST, were required during HSC transplantation to efficiently reconstitute the hematopoietic system of lethally irradiated mice.

[Blood] Using CRISPR-CAS9 gene editing technology, researchers generated knock-in mouse models that recapitulated the main features of X-linked sideroblastic anemia and X-linked protoporphyria.

[Cancer Cell] Deleting Arid1a in activated murine B cells disrupted IRF4-dependent transcriptional networks and blocked plasma cell differentiation.

[Annals of Hematology] Data from patients diagnosed with refractory anemic primary or post-essential thrombocythemia/polycythemia vera myelofibrosis, who were treated with luspatercept for at least nine weeks, were retrospectively collected.

[Molecular Therapy] Immune profiling indicated TILT-322 increased gamma delta T cell activation and impacted other cell types such as natural killer cells, and natural killer-like T cells that are traditionally involved in cancer immunotherapy.

[BMC Medicine] Researchers conducted an exploratory analysis of data from a phase Ib, dose-escalation, randomized, placebo-controlled study of IMCY-0098 in patients with recent-onset type 1 diabetes. A panel of markers of T cell activation, memory T cells, and effector T cell response were analyzed via descriptive statistics.