Investigators examined the transcriptomic profile of adipose-resident eosinophils and posit that KLF3 regulates adipose tissue function via transcriptional control of secreted molecules linked to beiging.
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Investigators found that human and mouse macrophages underwent a switch to glycolysis in response to IgG immune complex stimulation, mirroring macrophage metabolic changes in inflamed tissue in vivo. This metabolic reprogramming was required to generate a number of proinflammatory mediators, including IL-1β, and was dependent on mTOR and hypoxia-inducible factor-1α.
[Proceedings of the National Academy of Sciences of the United States of America]
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Researchers investigated the impact of acute local allergen exposure on the frequency and phenotype of tissue eosinophils within remote mucosal organs.
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Scientists explored how using a synthetic cell-penetrating peptide mimic for intracellular anti-protein kinase C theta delivery fine-tuned differentiation of induced regulatory T cells, through its differential effects on RNA processing.
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Investigators established that bovine peripheral leukocytes express all known serotonin receptors, and can synthesize, uptake and degrade serotonin due to the expression of serotonin metabolism-related genes.
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Scientists demonstrated extensive nerve fibers in all splenic compartments including the splenic nodules, periarteriolar lymphoid sheath, marginal zones, trabeculae, and red pulp; close associations of nerve fibers with blood vessels; and close associations of nerve fibers with various subsets of dendritic cells, macrophages, and lymphocytes
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To explore the role of the spleen and splenic macrophages, key players in the cholinergic anti-inflammatory pathway, splenectomy, and adoptive transfer of macrophages treated with the selective α7 nicotinic acetylcholine receptor agonist GTS-21 were conducted.
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The flowcytometric analysis shows the expression of G protein coupled receptor 35 (GPR35) on the infiltrating monocytes/macrophages and neutrophils in the ischemic brain.
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X-SCID rabbits presented immunodeficient phenotypes including the loss of T and B cells and hypoplasia of the thymus.
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Using a syngeneic hepatoceullar carcinoma (HCC) mouse model, the authors demonstrated that treatment with apatinib resulted in attenuation of tumor growth and increased tumor vessel normalization. Results indicated that NK cells, but not CD4+ or CD8+ T cells mediated the therapeutic efficacy of apatinib in HCC mouse models.
[Cancer Gene Therapy]
The authors assessed expression of genes encoding the heterodimeric IL-27 cytokine and constituent subunits of the Il-27 receptor in rheumatoid arthritis, including in extra-articular, subcutaneous rheumatoid nodules.
[Genes and Immunity]
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