Publication

[Journal Of Nanobiotechnology] The authors found that glioma-associated-MSCs promoted the expression of CD73, an ectonucleotidase that drove immunosuppressive microenvironment maintenance by generating adenosine, on myeloid-derived suppressor cells through immunosuppressive exosomal miR-21 signaling.

[Discover Oncology] Scientists used propofol to treat LOVO and SW480 cells and Cell Counting Kit-8 to detect proliferation. Self-renewal capacity, cell invasion and migration, flow cytometry analysis, qPCR and Western blotting were performed to detect the suppression of propofol to colon cancer cells and the underlying mechanism.

[ACS Nano] Experimental results indicate that glucosamine-labeled liposomal ceramide can be efficiently transported between cancer cells by GLUT1 transporters and substantially accumulated in the hypoxic area in in vitro CSC spheroids and in vivo tumor xenografts.

[Chinese Medical Journal] Gastric cancer stemness influenced by B7-H3 was detected both in vitro and in vivo. The expression of stemness-related markers was examined by reverse transcriptase quantitative polymerase chain reaction, Western blotting, and flow cytometry.

[Journal Of Gene Medicine] CD44+/CD133+ human ovarian cancer stem cells (OCSCs) were isolated from human ovarian cancer tissues. OCSCs were interfered with using anisomycin and specific small-interfering RNA.

[Journal Of Translational Medicine] To target the cell surface GRP78, CAR-T cells based on its binding peptide were generated. In vitro two GBM cell lines and glioma stem cells were used to confirm the localization of csGRP78 and the cytotoxicity of the CAR-T cells.