Publication

[Cell Stem Cell] Scientists showed that Tet2 deficiency significantly facilitated leukemogenesis in various AML models through promoting homing of leukemia stem cells into bone marrow niche to increase their self-renewal/proliferation.

[EMBO Molecular Medicine] The authors tested the hypothesis that donor cell conditioning with the glucocorticoid fluticasone propionate prior to transplantation could increase hematopoietic stem cell engraftment and reduce graft-versus-host disease.

[Leukemia] Researchers employed an inducible kinase-inactive D2338A mTOR knock-in mouse model together with a mTOR conditional knockout model to assess the kinase-dependent/-independent function of mTOR in hematopoiesis and the on-/off-target effects of mTOR kinase inhibitor AZD2014.

[Stem Cells] To investigate the effects of perturbing the cohesin subunit protein RAD21 on normal hematopoiesis, investigators employed conditional knockout mouse models.

[Cell Death & Disease] Using a single-cell assay to track individual cells that exit a drug-induced senescence-like state, scientists showed that cells exhibited asynchronous exit from a senescent-like state and displayed different rates of proliferation.

[Cancer Gene Therapy] The authors reported a case of AML with a mutation in the NPM1 gene and a subclonal gene rearrangement involving the PDGFRB gene.