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Identifying Physiological Tissue Niches That Support the HIV Reservoir in T Cells

[mBio] Investigators discuss the cellular and molecular cues that are important for memory T cell homeostasis and highlight opportunities for HIV to hijack normal immunological processes to establish long-term viral persistence.

SHIP1 and Its Role for Innate Immune Regulation – Novel Targets for Immunotherapy

[European Journal Of Immunology] Scientists summarize our current knowledge of SHIP1 with a focus on innate immune cells, where they reflect on the most pertinent aspects described in the current literature.

Muscle: An Independent Contributor to the Neuromuscular Spinal Muscular Atrophy Disease Phenotype

[JCI Insight] The authors discuss how survival motor neuron (SMN) might regulate the health of myofibers and their progenitors. They also speculate on therapeutic outcomes of failing to raise muscle SMN to healthful levels and present strategies to restore function to this tissue to ensure better treatment results.

Extracellular Matrix-Induced Signaling Pathways in Mesenchymal Stem/Stromal Cells

[Cell Communication and Signaling] The authors consider the existing evidence regarded the contribution of extracellular matrix-induced intracellular signaling pathways into the regulation of stem cell differentiation focusing on MSCs as well-studied type of postnatal stem cells totally depended on signals from ECM.

Stem Cell-Derived Organoid Models for SARS-CoV-2 and Its Molecular Interaction with Host Cells

[Molecular Biology Reports] There is an urgent need for physiological models to study SARS-CoV-2 infection during the pandemic. Human stem cell-derived organoids can provide insight into understanding the SARS-CoV-2 cell entry molecular mechanism.

Emerging Nanotechnological Approaches to Regulating Tumor Vasculature for Cancer Therapy

[Journal Of Controlled Release] Scientists describe the morphological and functional characteristics of tumor blood vessels and summarize the pivotal molecular targets commonly used in nanomedicine design, and then highlight the recent cutting-edge advancements utilizing nanotechnologies for precise regulation of tumor vasculature.

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