Review

[Molecular Diagnosis & Therapy] Investigators discuss current and future strategies being developed to optimize chimeric antigen receptor (CAR) T cells for efficacy in patients with glioblastoma.

[Stem Cell Research & Therapy] Scientists summarize recent approaches used to promote hiPSC-cardiomyocyte (CM) proliferation, and thoroughly review recent advances in promoting hiPSC-CM maturation, which will serve as the foundation for large-scale production of mature hiPSC-CMs for future clinical applications.

[Cancer Medicine] The authors review the targeting of CSCs by immunotherapy strategies such as dendritic cell vaccines, chimeric antigen receptors-engineered immune cells, natural killer-cell therapy, monoclonal antibodies, and more.

[Lancet Respiratory Medicine] Scientists summarize key questions about cystic fibrosis disease in the era of modulator therapy, highlighting state-of-the-art research and clinical practices, knowledge gaps, and new challenges faced by most people with cystic fibrosis.

[Annals Of Pharmacotherapy] The authors evaluate the safety and efficacy of the novel KRAS-targeting agents, sotorasib and adagrasib, in treating KRAS G12C-mutated NSCLC.

[Therapeutic Advances In Hematology] The authors focus on umbilical cord blood transplantation, benefits and barriers to using this alternative donor source, and finally the potential advancements with incorporation of omidubicel in the transplant setting for malignant and non-malignant diseases.