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Emerging Nanotechnological Approaches to Regulating Tumor Vasculature for Cancer Therapy

[Journal Of Controlled Release] Scientists describe the morphological and functional characteristics of tumor blood vessels and summarize the pivotal molecular targets commonly used in nanomedicine design, and then highlight the recent cutting-edge advancements utilizing nanotechnologies for precise regulation of tumor vasculature.

Melatonin as a Therapeutic Agent for Alleviating Endothelial Dysfunction in Cardiovascular Diseases: Emphasis on Oxidative Stress

[Biomedicine & Pharmacotherapy] Based on bibliometric studies, the authors first discuss the relationship between oxidative stress-induced endothelial dysfunction and cardiovascular diseases, then summarize the role of melatonin in the treatment of atherosclerosis, hypertension, myocardial ischemia-reperfusion injury, and other cardiovascular diseases.

Chimeric Antigen Receptor Therapy Meets mRNA Technology

[Trends In Biotechnology] The authors summarize recent advances in mRNA-based CAR immunotherapies and highlight their opportunities and challenges for the development of a new generation of living drugs.

Downregulation of RCN1 Promotes Pyroptosis in Acute Myeloid Leukemia Cells

[Journal Of Clinical Apheresis] Hematopoietic stem cell transplantation is a life-saving procedure that requires mobilization of stem cells for apheresis procedure. The authors aimed to examine mobilizing agents that are in use and under investigation.

Microenvironment in Acute Myeloid Leukemia: Focus on Senescence Mechanisms, Therapeutic Interactions and Future Directions

[Experimental Hematology] Scientists discuss the central role of the microenvironment in physiologic and pathologic hematopoiesis and the mechanisms of senescence, considered a fundamental protective mechanism against the proliferation of damaged and pre-tumoral cells.

Skin Cancer Prevention – Recent Advances and Unmet Challenges

[Cancer Letters] Investigators review the epidemiology, risk factors, and current cutaneous squamous cell carcinoma (cSCC) prevention strategies. They highlight the gaps and future clinical strategies to address cSCC risk in high-risk populations.

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