Review

[Biomedicine & Pharmacotherapy] In the early stages of systemic sclerosis development, endothelial cell injury and apoptosis can lead to vascular and perivascular inflammation, oxidative stress, and tissue hypoxia, which can cause clinical manifestations in various organs from the skin to the parenchymal organs.

[Nature Cardiovascular Research] Scientists analyze how extracellular matrix (ECM) mechanics regulate vascular homeostasis and dysfunction, highlighting approaches to examine ECM mechanics at tissue and cellular levels, focusing on how mechanical interactions between cells and the ECM regulate vascular phenotype, especially under certain pathological conditions.

[Signal Transduction And Targeted Therapy] The authors review historical perspectives on the applications and clinical considerations of immunotherapy. They first outline the recent advances that have been made in the understanding of the various categories of immunotherapies in the treatment of hematologic malignancies.

[Nature Reviews Gastroenterology & Hepatology] Scientists analyze existing data on the interaction between alcohol consumption and metabolic syndrome as well as the overlapping features and differences in the pathogenesis of alcohol-related liver disease and nonalcoholic fatty liver disease.

[Trends In Biotechnology] The authors outlined recently developed organ-on-a-chip platforms and discuss the features needed for reliable prediction of sensitizing allergenicity of proteins.

[Frontiers in Oncology] The authors highlights the advancements in prostate cancer therapeutics and new drug molecules against prostate cancer.