Review

[Gastroenterology Report] Scientists comprehensively summarize the tissue source including human fetal and adult pancreatic tissue to generate a pancreatic organoid as well as current organoids cultivate system.

[Cell Communication and Signaling] The authors focus on the acquired resistance to osimertinib caused by EGFR mutations which account for approximately 1/3 of all reported resistance mechanisms in NSCLCs.

[Journal of Cellular Physiology] The authors discuss the roles of poly(ADP-ribose) polymerase (PARP) in mediating DNA repair processes in breast epithelial cells, mechanisms of PARPi resistance in TNBC, and recent advances in the development of agents designed to overcome PARPi resistance in TNBC.

[Cell Death Discovery] The authors describe the various origin and heterogeneous activation mechanisms of cancer-associated fibroblasts (CAFs), and biological heterogeneity of CAFs in head and neck squamous cell carcinoma is also included.

[Frontiers In Oncology] Scientists cover current strategies targeting myeloid suppressor cells in the TME to enhance anti-tumoral immunity, including strategies that target chemokine receptors to deplete selected immune suppressive myeloid cells and relieve the inhibition imposed on the effector arms of adaptive immunity.

[Medicinal Research Reviews] The authors describe the structural features and functions of lysine demethylases (KDMs), the KDMs preferences of different cancers, and the mechanisms of drug resistance resulting from KDMs.