Review

[Leukemia] Leukemogenesis occurs and progresses in extracellular microvesicles enriched microenvironments. The authors present a current point of view on this topic and review some selected most recent discoveries and papers.

[Translational Psychiatry] The authors contrast advantages and disadvantages of each of these six cell-based methodologies. Neuronal-like cells derived from pluripotent monocytes are presented in more detail as this technique was recently used in psychiatry for the first time.

[iScience] The authors explore the communication function and mechanism of exosomes derived from different cells in cancer metastasis, while also presenting an outlook on current research advancements and future application prospects.

[Cancer Gene Therapy] Researchers evaluate the utilization strategies of cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) across various subpopulations of breast cancer and explore potential therapeutic avenues following disease progression during application of CDK4/6i therapy.

[Cancer Stem Cell News, Intestinal Cell News] New evidence suggests that colorectal CSCs manifest substantial heterogeneity, as exemplified by the existence of both actively cycling Lgr5+ CSCs as well as quiescent Lgr5+ CSCs that are resistant to conventional anticancer therapies.

[Neuro-Oncology] Scientists provide a historical perspective on the CSC hypothesis and its recent evolution, with a focus on key functional phenotypes, and provide an update on the definition for its use in future genomic studies.