Review

[Nature Reviews Endocrinology] Scientists discuss mechanisms that regulate carbohydrate-responsive element binding protein activity in a tissue-specific manner and their respective roles in controlling de novo lipogenesis and beyond.

[Science] The authors discuss recent discoveries, including attribution of central nervous system immune surveillance to tissue-resident microglia and acknowledging the existence of a complex brain-immune network that involves multiple peripheral immunological players.

[Nature Reviews Rheumatology] Scientists review ongoing efforts to dissect cellular and molecular heterogeneity in systemic lupus erythematosus (SLE), and how they could facilitate the future development of stratified treatment recommendations and precision medicine, which is a considerable challenge for SLE.

[Nature Immunology] The authors review the complex function of adipose tissue macrophages in adipose tissue homeostasis and metabolic inflammation.

[Nature Reviews Gastroenterology & Hepatology] The authors outline the management of inflammatory bowel disease (IBD) in pregnancy and the safety of IBD therapies, including novel agents, with regard to both maternal and fetal health.

[Biomolecules & Biomedicine] Investigators summarize the pathophysiological mechanisms and available targeted therapies for prostate cancer.