Exosomes: Roles and Therapeutic Potential in Osteoarthritis

The authors summarize the roles and therapeutic potential of exosomes in osteoarthritis and discusses the perspectives and challenges related to exosome-based treatment for osteoarthritis patients in the future.
[Bone Research]
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MLLT10 in Benign and Malignant Hematopoiesis

The authors examine aspects of Mixed Lineage Leukemia Translocated to, 10 (MLLT10), contextualizing its function in benign and malignant hematopoiesis.
[Experimental Hematology]
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Prognostic Value of Circulating Tumor Cells Detected with the CellSearch System in Esophageal Cancer Patients: A Systematic Review and Meta-Analysis

The authors demonstrated that circulating tumor cells positivity determined by the CellSearch system were correlated with the prognosis of esophageal carcinoma (EC) patients and might indicate a poor therapeutic response to chemotherapy in EC patients.
[BMC Cancer]
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Regenerative Potential of Wharton’s Jelly‐Derived Mesenchymal Stem Cells: A New Horizon of Stem Cell Therapy

The authors summarize the current preclinical and clinical studies performed to investigate the regenerative potential of Wharton’s jelly‐derived mesenchymal stem cells in neural, myocardial, skin, liver, kidney, cartilage, bone, muscle, and other tissue injuries.
[Journal of Cellular Physiology]
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Regenerative Potential of Wharton’s Jelly-Derived Mesenchymal Stem Cells: A New Horizon of Stem Cell Therapy

The authors summarize the current preclinical and clinical studies performed to investigate the regenerative potential of WJ‐MSCs in neural, myocardial, skin, liver, kidney, cartilage, bone, muscle, and other tissue injuries.
[Journal of Cellular Physiology]
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COVID-19 Revisiting Inflammatory Pathways of Arthritis

The pattern of pro-inflammatory cytokines induced in COVID-19 has similarities to those targeted in the treatment of rheumatoid arthritis. Several clinical studies are underway that test the effects of inhibiting IL-6, IL-1β or TNF or targeting cytokine signaling via Janus kinase inhibition in the treatment of COVID-19.
[Nature Reviews Rheumatology]
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Pleiotropic Role of Notch Signaling in Human Skin Diseases

The authors describe the role of Notch signaling in the skin, particularly focusing on the principal consequences associated with its alterations in five human skin diseases, in order to reorganize the current knowledge and to identify potential cellular mechanisms in common between these pathologies.
[International Journal of Molecular Sciences]
Gratton, R., Tricarico, P. M., Moltrasio, C., Lima Estevão de Oliveira, A. S., Brandão, L., Marzano, A. V., Zupin, L., & Crovella, S. (2020). Pleiotropic Role of Notch Signaling in Human Skin Diseases. International Journal of Molecular Sciences, 21(12), 4214. https://doi.org/10.3390/ijms21124214 Cite
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Intracellular Calcium Leak in Heart Failure and Atrial Fibrillation: A Unifying Mechanism and Therapeutic Target

The authors focus on the mechanisms that regulate ryanodine receptor 2 (RYR2), the major sarcoplasmic reticulum Ca2+-release channel in the heart, and how RYR2 becomes dysfunctional in heart failure and atrial fibrillation.
[Nature Reviews Cardiology]
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Advanced Prostate Cancer: Treatment Advances and Future Directions

The authors summarize clinical trials leading to recent drug approvals and discuss optimal treatment selection.
[Trends in Cancer]
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Prostate Carcinogenesis: Inflammatory Storms

Scientists provide updates on recent advances in elucidating prostate carcinogenesis and explore novel therapeutic and prevention strategies harnessing these discoveries.
[Nature Reviews Cancer]
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The Vascular Endothelium: The Cornerstone of Organ Dysfunction in Severe SARS-CoV-2 Infection

Venous thrombotic events, particularly pulmonary embolism, with elevated D-dimer and coagulation activation are highly prevalent in COVID-19 patients. The pro-inflammatory cytokine storm, with elevated levels of interleukin-6 (IL-6), IL-2 receptor, and tumor necrosis factor-α, could also participate in endothelial dysfunction and leukocyte recruitment in the microvasculature.
[Critical Care]
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