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Patient-Derived Organoids as Therapy Screening Platforms in Cancer Patients

[Advanced Healthcare Materials] The authors summarize recent advancements in patient-derived organoids (PDO) development and the enhancement of PDO culture models.

Calcium Signaling in Airway Epithelial Cells: Current Understanding and Implications for Inflammatory Airway Disease

[Arteriosclerosis Thrombosis And Vascular Biology] The authors discuss the role of major Ca2+ signaling pathways found in airway epithelial cells and their roles in mediating airway inflammation, mucociliary clearance, and surfactant production.

Plant-Derived Vesicle-Like Nanoparticles: A New Tool for Inflammatory Bowel Disease and Colitis-Associated Cancer Treatment

[Molecular Therapy] The authors summarize the latest advances in research on the sources and extraction methods, applications, and mechanisms in IBD and colitis-associated cancer therapy, overcoming drug resistance, safety, stability, and clinical application of plant-derived vesicle-like nanoparticles.

The Dark Side of Stemness – the Role of Hematopoietic Stem Cells in Development of Blood Malignancies

[Frontiers in Oncology] The authors review the evidence supporting the role of preleukemic HSCs in different types of blood cancers, as well as present the alternative models of malignant evolution.

Phenotypic Transitions the Processes Involved in Regulation of Growth and Proangiogenic Properties of Stem Cells, Cancer Stem Cells and Circulating Tumor Cells

[Stem Cell Reviews And Reports] Circulating tumor cells exhibit molecular diversity and stem-like and mesenchymal features, even when derived from primary tumor tissue from a single patient.

Epigenetic Reprogramming in the Transition from Pluripotency to Totipotency

[Journal of Cell Physiology] The authors highlight the recent findings in understanding the mechanisms of epigenetic remodeling during totipotency capture, including RNA splicing, DNA methylation, chromatin configuration, histone modifications, and nuclear organization.

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