Review

[Journal of Translational Medicine] The authors comprehensively review the regulatory mechanisms related to the functions of ncRNAs and the Wnt/β-catenin pathway in lung cancer.

[Cancer Cell] The authors highlight recent clinical success of immune checkpoint therapy in the neoadjuvant setting, where treatment is given in earlier disease stages to improve outcomes and explore how neoadjuvant clinical trials could be utilized to drive mechanistic laboratory-based investigations.

[Lung] Investigators systematically examine the structural and functional features of histone deacetylase 3 (HDAC3) and discuss its multifaceted contributions to pulmonary pathologies, including lung injury, pulmonary fibrosis, and lung cancer.

[Tissue Engineering Part C-Methods] Investigators underscore PKM2’s role in HCC development, influencing both glycolytic metabolism and oncogenic signaling pathways like PI3K/AKT/mTOR and MAPK.

[Signal Transduction and Targeted Therapy] Scientists propose three mechanisms with determinant roles on systemic lupus erythematosus initiation and progression: attenuating the immune system, restoring the cytokine microenvironment homeostasis, and rescuing the impaired debris clearance machinery

[Nature Reviews Immunology] The authors consider how studies provide scientific basis for future exploration of SUMO-mediated immune modulation for the treatment of cancers and autoimmune disorders.