The authors summarize the roles and therapeutic potential of exosomes in osteoarthritis and discusses the perspectives and challenges related to exosome-based treatment for osteoarthritis patients in the future.
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The authors examine aspects of Mixed Lineage Leukemia Translocated to, 10 (MLLT10), contextualizing its function in benign and malignant hematopoiesis.
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The authors demonstrated that circulating tumor cells positivity determined by the CellSearch system were correlated with the prognosis of esophageal carcinoma (EC) patients and might indicate a poor therapeutic response to chemotherapy in EC patients.
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The authors summarize the current preclinical and clinical studies performed to investigate the regenerative potential of Wharton’s jelly‐derived mesenchymal stem cells in neural, myocardial, skin, liver, kidney, cartilage, bone, muscle, and other tissue injuries.
[Journal of Cellular Physiology]
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The authors summarize the current preclinical and clinical studies performed to investigate the regenerative potential of WJ‐MSCs in neural, myocardial, skin, liver, kidney, cartilage, bone, muscle, and other tissue injuries.
[Journal of Cellular Physiology]
The pattern of pro-inflammatory cytokines induced in COVID-19 has similarities to those targeted in the treatment of rheumatoid arthritis. Several clinical studies are underway that test the effects of inhibiting IL-6, IL-1β or TNF or targeting cytokine signaling via Janus kinase inhibition in the treatment of COVID-19.
[Nature Reviews Rheumatology]
The authors describe the role of Notch signaling in the skin, particularly focusing on the principal consequences associated with its alterations in five human skin diseases, in order to reorganize the current knowledge and to identify potential cellular mechanisms in common between these pathologies.
[International Journal of Molecular Sciences]
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Gratton, R., Tricarico, P. M., Moltrasio, C., Lima Estevão de Oliveira, A. S., Brandão, L., Marzano, A. V., Zupin, L., & Crovella, S. (2020). Pleiotropic Role of Notch Signaling in Human Skin Diseases. International Journal of Molecular Sciences, 21(12), 4214. https://doi.org/10.3390/ijms21124214 Cite
The authors focus on the mechanisms that regulate ryanodine receptor 2 (RYR2), the major sarcoplasmic reticulum Ca2+-release channel in the heart, and how RYR2 becomes dysfunctional in heart failure and atrial fibrillation.
[Nature Reviews Cardiology]
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The authors summarize clinical trials leading to recent drug approvals and discuss optimal treatment selection.
[Trends in Cancer]
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Scientists provide updates on recent advances in elucidating prostate carcinogenesis and explore novel therapeutic and prevention strategies harnessing these discoveries.
[Nature Reviews Cancer]
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Venous thrombotic events, particularly pulmonary embolism, with elevated D-dimer and coagulation activation are highly prevalent in COVID-19 patients. The pro-inflammatory cytokine storm, with elevated levels of interleukin-6 (IL-6), IL-2 receptor, and tumor necrosis factor-α, could also participate in endothelial dysfunction and leukocyte recruitment in the microvasculature.
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