Review

[Cell Regeneration] The authors conduct a comprehensive research to further understand the intertwine between the mechanisms of action of intervertebral disc (IVD) components and the therapeutic potential of MSCs, exploring their characteristics, and how to optimize their use and establish them safely in distinct settings for low back pain treatment.

[mBio] The authors provide an overview of the current knowledge regarding how lncRNAs regulate HIV gene expression, categorizing them as either activators or inhibitors of viral gene expression and infectivity.

[Cellular & Molecular Immunology] Scientists focused on asymptomatic infections, a widely reported phenomenon that has substantially contributed to the rapid spread of the pandemic.

[Metabolism Clinical And Experimental] The authors summarize the latest developments in bioengineering functional islet organoids in vitro and promoting vascularization of organoid grafts before and after transplantation.

[Science Signaling] Investigators summarize their knowledge of the roles of these NF-κB pathways, which are activated in different intestinal cell types by specific ligands, and their cross-talk, in fueling aberrant intestinal inflammation.

[Nature Reviews Rheumatology] The registrational clinical trials and registry data of JAK inhibitors did not identify a difference in the risk of major adverse cardiovascular events, venous thromboembolism, malignancies or infections with a JAK inhibitor versus a biologic DMARD.