Review

[The Journal of Gene Medicine] The authors provide an overview of current preclinical approaches in that lipid nanoparticle surface modification was leveraged for cell and tissue targeting by conjugating aptamers, antibodies, and peptides among others.

[Nature Reviews Drug Discovery] Investigators discuss recent advances in understanding the molecular and cellular pathways that impair synapses in neurodegenerative diseases, including the effects of protein aggregation and neuroinflammation.

[Heliyon] The authors summarize the roles of mechanosensitive ion channels in immune cells.

[Nature Reviews Gastroenterology & Hepatology] The authors provide an overview of the clinical evidence regarding disease staging, preoperative therapy, response evaluation and surgery in patients with borderline resectable pancreatic cancer or locally advanced pancreatic cancer.

[Stem Cell Reports] Investigators discuss the limbal stem cell model and its broader relevance to other tissues, disease, and therapy.

[Pflugers Archiv-European Journal Of Physiology] The authors suggest the causal relationship between peroxisome proliferator–activated receptor γ coactivator-1α (PGC-1α) regulation and effective modulations of mitochondrial biogenesis and metabolic flexibility during the different stages of disease development.