vascular endothelial cells

[Scientific Reports] The authors investigated the role of endothelial-derived extracellular microRNA-92a in promoting arterial stiffness by regulating endothelial cell–vascular smooth muscle cell communication.

[Archives of Biochemistry and Biophysics] Investigators summarize regulatory factors and signaling mechanisms of regulatory death in endothelial cells, discussing their effects in the context of the atherosclerotic procession.

[Journal of Clinical Investigation] Investigators described two siblings with recurrent skin ulcers that healed with scar formation upon corticosteroid treatment and characterized ISG15-/- dermal fibroblasts, HaCaT keratinocytes, and human induced pluripotent stem cell-derived vascular endothelial cells.

[Clinical and Translational Oncology] Scientists investigated the involvement of the SDF-1/CXCR4 axis in the process of bone marrow mesenchymal stem cells (BMMSC) homing in prostate cancer (PCa) in vivo and in vitro and suggested that BMMSCs could home and promote the proliferation and migration of PCa through the SDF-1/CXCR4 axis.

[Nature Communications] Researchers reported that bone marrow (BM) vascular endothelial cells secreted semaphorin 3 A (SEMA3A) in response to myeloablation and SEMA3A induced p53 – mediated apoptosis in BM endothelial cells via signaling through its receptor, Neuropilin 1 (NRP1), and activation of cyclin dependent kinase 5.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators revealed that IκB kinase (IKK)-α in distinct endothelial cell (EC)-derived compartments was uniquely required to promote B cell homeostasis and lymph node (LN) development, and they established that lymphatic EC-intrinsic IKK-α was absolutely essential for LN formation.