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Wnt/β-catenin

3D Bioprinted GelMA-Nanoclay Hydrogels Induce Colorectal Cancer Stem Cells through Activating Wnt/β-Catenin Signaling

[Small] The authors found that gelatin methacryloyl (GelMA)-nanoclay hybrid hydrogels could induce and enrich colorectal cancer stem cells assisted by three-dimensional bioprinting.

Inhibition of DCLK1 Sensitizes Resistant Lung Adenocarcinomas to EGFR-TKI through Suppression of Wnt/β-Catenin Activity and Cancer Stemness

[Cancer Letters] The authors investigated the role of the tumor stem cell marker DCLK1 in epithelial growth factor receptor-tyrosine kinase inhibitor resistance of lung adenocarcinoma.

BRCC36 Prevents Vascular Calcification in Chronic Kidney Disease through the β-Catenin Signalling Pathway

[Experimental Cell Research] Researchers established an in vitro VC model of vascular smooth muscle cells (VSMCs) and an adenine-induced CKD mouse model.

Human Umbilical Cord Mesenchymal Stem Cells Derived Exosomes Promote Neurological Function Recovery in a Rat Spinal Cord Injury Model

[Neurochemical Research] Researchers explored the mechanism of hUC-MSC derived exosome's ameliorative effect on the spinal cord injury by combining data from in vivo contusion spinal cord injury model and in vitro cell viability of PC12 cell line stimulated with lipopolysaccharide.

Scrapie-Responsive Gene 1 Promotes Chondrogenic Differentiation of Umbilical Cord Mesenchymal Stem Cells via Wnt5a

[Stem Cell International] Expression of SCRG1 was detected in umbilical cord-derived MSCs by quantitative reverse transcription polymerase chain reaction and immunohistochemical analysis during chondrogenic differentiation.

Exendin-4 Alleviates Steatosis in an In Vitro Cell Model by Lowering FABP1 and FOXA1 Expression via the Wnt/-Catenin Signaling Pathway

[Scientific Reports] The authors investigated the mechanisms underlying the protective effect of glucagon-like peptide-1 receptor (GLP-1R) on non-alcoholic fatty liver disease using an in vitro model of steatosis treated with the GLP-1R agonist Exendin-4.

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