Wnt/β-catenin

[Cell Death & Disease] The authors identified a lncRNA, HOMER3-AS1, which was over-expressed in hepatocellular carcinoma (HCC) and correlated with poor survival of HCC patients. HOMER3-AS1 promoted HCC cellular proliferation, migration, and invasion, and reduced HCC cellular apoptosis.

[Cellular Signalling] Scientists examined the regulatory effects of ZRANB1 on the maintenance of CSC properties and tumor growth in colorectal cancer.

[Science Immunology] Scientists showed that activation of the WNT/β-catenin signaling pathway contributed to the development of a noninflamed tumor microenvironment in tumors with high tumor mutation burden.

[Experimental Cell Research] Researchers explored the efficacy of the domains of secreted frizzled-related protein 4 (sFRP4) in inhibiting the key hallmarks of glioblastoma such as invasion, metastasis, and stemness.

[Cell Reports] Scientists showed that Myc-driven hepatocellular carcinoma was dramatically aggravated in mice with hepatocyte-specific Ptpn11/Shp2 deletion.

[Oncogene] Investigators found that inhibition or knockout of endogenous, mature microRNA-3662 in TNBC cells suppressed proliferation and migration in vitro and tumor growth and metastasis in vivo.