Wnt/β-catenin

[Science Advances] Researchers demonstrated long-term regrowth, marked tissue repatterning, and functional restoration of an amputated Xenopus laevis hindlimb following a 24-hour exposure to a multidrug, pro-regenerative treatment delivered by a wearable bioreactor.

[Signal Transduction and Targeted Therapy] Investigators performed whole-genome sequencing on 40 pairs of primary and early-recurrent hepatitis B virus (HBV)-related hepatocellular carcinoma tumors from patients who received curative resection, and from four patients whose primary and recurrent tumor were extensively sampled.

[Biochimie] The authors reviewed the recent progress of this signal transduction pathway in colorectal tumorigenesis.

[Molecular Biotechnology] Stem cells from colorectal cancer HCT116 and CACO2 cells were isolated. TPT1-AS1 was significantly highly expressed in the CSCs compared to non-stem cells.

[Scientific Reports] The authors examined the role of B-cell CLL/lymphoma 9 (BCL9), which is downstream of hypoxia-inducible factor 1α and a Wnt/β-catenin transcriptional cofactor, in the osteo/odontoblastic differentiation of human dental pulp stem cells under hypoxic conditions.

[Biomedicine & Pharmacotherapy] Scientists discuss the latest developments in breast cancer stem cells (BCSCs) research, focusing on the analysis of specific markers, critical signaling pathways that maintain the stemness of BCSCs, such as NOTCH, Wnt/β-catenin, STAT3, Hedgehog, and Hippo-YAP signaling.