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Pulmonary Cell NewsAn unbiased RNA-seq approach was developed to interrogate DAC-induced transcriptome changes in AML cell lines with or without a deletion of chromosomes 7q, 5q or 17p. Hypomethylating agent treatment preferentially upregulated several hemizygous tumor suppressor genes in this genomic region, significantly derepressing endogenous retrovirus (ERV)3-1 with promoter demethylation, enhanced chromatin accessibility, and increased H3K4me3 levels.
[Cancer Research]
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Greve, G., Schüler, J., Grüning, B. A., Berberich, B., Stomper, J., Zimmer, D., Gutenkunst, L., Bönisch, U., Meier, R., Blagitko-Dorfs, N., Grishina, O., Pfeifer, D., Weichenhan, D., Plass, C., & Lübbert, M. (2020). Decitabine induces gene derepression on monosomic chromosomes: in vitro and in vivo effects in adverse-risk cytogenetics AML. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-1430 Cite
