ATP-Binding Cassette Transporters Restrict Drug Delivery and Efficacy against Brain Tumors Even when Blood-Brain Barrier Integrity Is Lost

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Justin.choi
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A leaky vasculature resulted in higher docetaxel tumor levels compared to normal brain. Nevertheless, Abcb1 could reduce drug distribution and efficacy even in leaky models.
[Cell Reports Medicine]
Gooijer, M. C. de, Kemper, E. M., Buil, L. C. M., Çitirikkaya, C. H., Buckle, T., Beijnen, J. H., & Tellingen, O. van. (2021). ATP-binding cassette transporters restrict drug delivery and efficacy against brain tumors even when blood-brain barrier integrity is lost. Cell Reports Medicine, 2(1). https://doi.org/10.1016/j.xcrm.2020.100184 Cite
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