The authors showed that expression of the glucagon-like peptide-1 gene delivered by epidermal stem cells attenuated development and reinstatement of alcohol-induced drug-taking and seeking as well as voluntary oral alcohol consumption.
[Molecular Psychiatry]
6445218 NUVCCQZD items 1 apa 0 default asc 1 159288 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-26ffe564855d1b3d5fd544ff9041a62b%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22NUVCCQZD%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kong%20et%20al.%22%2C%22parsedDate%22%3A%222021-02-22%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EKong%2C%20Q.%2C%20Li%2C%20Y.%2C%20Yue%2C%20J.%2C%20Wu%2C%20X.%2C%20%26amp%3B%20Xu%2C%20M.%20%282021%29.%20Reducing%20alcohol%20and%5C%2For%20cocaine-induced%20reward%20and%20toxicity%20via%20an%20epidermal%20stem%20cell-based%20gene%20delivery%20platform.%20%3Ci%3EMolecular%20Psychiatry%3C%5C%2Fi%3E%2C%201%26%23x2013%3B11.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41380-021-01043-y%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41380-021-01043-y%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DNUVCCQZD%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Reducing%20alcohol%20and%5C%2For%20cocaine-induced%20reward%20and%20toxicity%20via%20an%20epidermal%20stem%20cell-based%20gene%20delivery%20platform%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qingyao%22%2C%22lastName%22%3A%22Kong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yuanyuan%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jiping%22%2C%22lastName%22%3A%22Yue%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiaoyang%22%2C%22lastName%22%3A%22Wu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ming%22%2C%22lastName%22%3A%22Xu%22%7D%5D%2C%22abstractNote%22%3A%22Alcohol%20use%20disorder%20%28AUD%29%20is%20one%20of%20the%20foremost%20public%20health%20problems.%20Alcohol%20is%20also%20frequently%20co-abused%20with%20cocaine.%20There%20is%20a%20huge%20unmet%20need%20for%20the%20treatment%20of%20AUD%20and%5C%2For%20cocaine%20co-abuse.%20We%20recently%20demonstrated%20that%20skin%20grafts%20generated%20from%20mouse%20epidermal%20stem%20cells%20that%20had%20been%20engineered%20by%20CRISPR-mediated%20genome%20editing%20could%20be%20transplanted%20onto%20mice%20as%20a%20gene%20delivery%20platform.%20Here%2C%20we%20show%20that%20expression%20of%20the%20glucagon-like%20peptide-1%20%28GLP1%29%20gene%20delivered%20by%20epidermal%20stem%20cells%20attenuated%20development%20and%20reinstatement%20of%20alcohol-induced%20drug-taking%20and%20seeking%20as%20well%20as%20voluntary%20oral%20alcohol%20consumption.%20GLP1%20derived%20from%20the%20skin%20grafts%20decreased%20alcohol-induced%20increase%20in%20dopamine%20levels%20in%20the%20nucleus%20accumbens.%20In%20exploring%20the%20potential%20of%20this%20platform%20in%20reducing%20concurrent%20use%20of%20drugs%2C%20we%20developed%20a%20novel%20co-grafting%20procedure%20for%20both%20modified%20human%20butyrylcholinesterase%20%28hBChE%29-%20and%20GLP1-expressing%20cells.%20Epidermal%20stem%20cell-derived%20hBChE%20and%20GLP1%20reduced%20acquisition%20of%20drug-taking%20and%20toxicity%20induced%20by%20alcohol%20and%20cocaine%20co-administration.%20These%20results%20imply%20that%20cutaneous%20gene%20delivery%20through%20skin%20transplants%20may%20add%20a%20new%20option%20to%20treat%20drug%20abuse%20and%20co-abuse.%22%2C%22date%22%3A%222021-02-22%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41380-021-01043-y%22%2C%22ISSN%22%3A%221476-5578%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41380-021-01043-y%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-02-22T19%3A17%3A27Z%22%7D%7D%5D%7D
Kong, Q., Li, Y., Yue, J., Wu, X., & Xu, M. (2021). Reducing alcohol and/or cocaine-induced reward and toxicity via an epidermal stem cell-based gene delivery platform. Molecular Psychiatry, 1–11. https://doi.org/10.1038/s41380-021-01043-y Cite