Autophagy Mediated Lipid Catabolism Facilitates Glioma Progression to Overcome Bioenergetic Crisis

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Using glioma patient database and human glioma cells, scientists assessed the mechanisms and function of selective autophagy to sustain mTORC1 hyper-activation in glioma.
[British Journal of Cancer]
Wang, C., Haas, M. A., Yeo, S. K., Paul, R., Yang, F., Vallabhapurapu, S., Qi, X., Plas, D. R., & Guan, J.-L. (2021). Autophagy mediated lipid catabolism facilitates glioma progression to overcome bioenergetic crisis. British Journal of Cancer, 1–13. https://doi.org/10.1038/s41416-021-01294-0 Cite
Abstract