Altered Perivascular Fibroblast Activity Precedes ALS Disease Onset

By
Justin.choi
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Investigators report that patients with sporadic myotrophic lateral sclerosis (ALS) present cell activity patterns consistent with two mouse models in which enrichments of vascular cell genes preceded microglial response.
[Nature Medicine]
Månberg, A., Skene, N., Sanders, F., Trusohamn, M., Remnestål, J., Szczepińska, A., Aksoylu, I. S., Lönnerberg, P., Ebarasi, L., Wouters, S., Lehmann, M., Olofsson, J., von Gohren Antequera, I., Domaniku, A., De Schaepdryver, M., De Vocht, J., Poesen, K., Uhlén, M., Anink, J., … Lewandowski, S. A. (2021). Altered perivascular fibroblast activity precedes ALS disease onset. Nature Medicine, 27(4), 640–646. https://doi.org/10.1038/s41591-021-01295-9 Cite
Abstract