Using multiple genetic approaches scientists showed that selective deletion of the PERK in mouse midbrain dopaminergic neurons resulted in multiple cognitive and motor phenotypes.
[Molecular Psychiatry]
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Longo, F., Mancini, M., Ibraheem, P. L., Aryal, S., Mesini, C., Patel, J. C., Penhos, E., Rahman, N., Mamcarz, M., Santini, E., Rice, M. E., & Klann, E. (2021). Cell-type-specific disruption of PERK-eIF2α signaling in dopaminergic neurons alters motor and cognitive function. Molecular Psychiatry, 1–24. https://doi.org/10.1038/s41380-021-01099-w Cite
