A Potential Role for Somatostatin Signaling in Regulating Retinal Neurogenesis

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By analyzing retinal explants treated with selective ligands that target these receptors, we found that Sstr2-dependent somatostatin signaling induces a modest, dose-dependent inhibition of photoreceptor generation, while correspondingly increasing the relative fraction of primary progenitor cells.
[Scientific Reports]
Weir, K., Kim, D. W., & Blackshaw, S. (2021). A potential role for somatostatin signaling in regulating retinal neurogenesis. Scientific Reports, 11(1), 10962. https://doi.org/10.1038/s41598-021-90554-3 Cite
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