Lithium Increases Mitochondrial Respiration in iPSC-Derived Neural Precursor Cells from Lithium Responders

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Researchers investigated the molecular effects ofLithium, valproate and lamotrigine treatment in induced pluripotent stem cell (iPSC)-derived neural precursor cells (NPCs) generated from three healthy controls, three affective disorder Li responsive patients and three Li non-treated patients after six hours and one week of exposure.
[Molecular Psychiatry]
Osete, J. R., Akkouh, I. A., de Assis, D. R., Szabo, A., Frei, E., Hughes, T., Smeland, O. B., Steen, N. E., Andreassen, O. A., & Djurovic, S. (2021). Lithium increases mitochondrial respiration in iPSC-derived neural precursor cells from lithium responders. Molecular Psychiatry, 1–17. https://doi.org/10.1038/s41380-021-01164-4 Cite
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