Glutathione Peroxidase-1 Regulates ASK1-Dependent Apoptosis via Interaction with TRAF2 in RIPK3-Negative Cancer Cells

Scientists showed that GPx type 1 (GPx1) played a key regulatory role in the apoptosis signaling pathway. The absence of GPx1 augmented TNF-α-induced apoptosis in various RIPK3-negative cancer cells by markedly elevating the level of cytosolic H2O2, which was derived from mitochondria.