Immunostaining was performed using liver sections of Caroli disease and polycystic liver disease, and the results were compared with those of congenital hepatic fibrosisand von Meyenburg complex.
[Pathology International]
7753456 {7753456:UTSE3C8X} apa 50 1 163897 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-5d69347184455baeab9dbbe39125b0f3%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22UTSE3C8X%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Takahashi%20et%20al.%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ETakahashi%2C%20K.%2C%20Sato%2C%20Y.%2C%20Yamamura%2C%20M.%2C%20Nakada%2C%20S.%2C%20Tamano%2C%20Y.%2C%20Sasaki%2C%20M.%2C%20%26amp%3B%20Harada%2C%20K.%20%28n.d.%29.%20Notch-Hes1%20signaling%20activation%20in%20Caroli%20disease%20and%20polycystic%20liver%20disease.%20%3Ci%3EPathology%20International%3C%5C%2Fi%3E%2C%20%3Ci%3En%5C%2Fa%3C%5C%2Fi%3E%28n%5C%2Fa%29.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fpin.13130%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fpin.13130%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3DUTSE3C8X%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Notch-Hes1%20signaling%20activation%20in%20Caroli%20disease%20and%20polycystic%20liver%20disease%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kenta%22%2C%22lastName%22%3A%22Takahashi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yasunori%22%2C%22lastName%22%3A%22Sato%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Minako%22%2C%22lastName%22%3A%22Yamamura%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Satoko%22%2C%22lastName%22%3A%22Nakada%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yuko%22%2C%22lastName%22%3A%22Tamano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Motoko%22%2C%22lastName%22%3A%22Sasaki%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kenichi%22%2C%22lastName%22%3A%22Harada%22%7D%5D%2C%22abstractNote%22%3A%22The%20Notch%20signaling%20pathway%20plays%20a%20key%20role%20in%20the%20morphogenesis%20of%20the%20biliary%20tree%2C%20but%20its%20involvement%20in%20cystic%20biliary%20diseases%2C%20such%20as%20Caroli%20disease%20%28CD%29%20and%20polycystic%20liver%20disease%20%28PLD%29%2C%20has%20yet%20to%20be%20determined.%20Immunostaining%20was%20performed%20using%20liver%20sections%20of%20CD%20and%20PLD%2C%20and%20the%20results%20were%20compared%20with%20those%20of%20congenital%20hepatic%20fibrosis%20%28CHF%29%20and%20von%20Meyenburg%20complex%20%28VMC%29.%20The%20expression%20of%20Notch%20receptor%201%20%28Notch1%29%20was%20increased%20in%20the%20nuclei%20of%20biliary%20epithelial%20cells%20in%20all%20cases%20of%20CD%20and%20PLD%2C%20whereas%20it%20remained%20at%20a%20low%20level%20in%20CHF%20and%20VMC.%20In%20addition%2C%20Notch2%20and%20Notch3%20were%20preferably%20expressed%20in%20the%20nuclei%20of%20biliary%20epithelial%20cells%20of%20PLD.%20Accordingly%2C%20the%20Notch%20effector%20Hes1%20was%20highly%20expressed%20in%20biliary%20epithelial%20cells%20of%20CD%20and%20PLD%2C%20and%20the%20cell%20proliferative%20activity%20was%20significantly%20higher%20in%20CD%20and%20PLD.%20The%20expression%20of%20the%20Notch%20ligand%20Delta-like%201%20was%20significantly%20increased%20in%20biliary%20epithelial%20cells%20of%20CD%20and%20PLD%2C%20which%20may%20be%20causally%20associated%20with%20the%20nuclear%20overexpression%20of%20Notch1%20and%20Hes1.%20These%20results%20indicate%20that%20aberrant%20activation%20of%20the%20Notch-Hes1%20signaling%20pathway%20may%20be%20responsible%20for%20the%20progression%20of%20biliary%20cystogenesis%20in%20CD%20and%20PLD.%22%2C%22date%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1111%5C%2Fpin.13130%22%2C%22ISSN%22%3A%221440-1827%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1111%5C%2Fpin.13130%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-06-25T18%3A40%3A46Z%22%7D%7D%5D%7D
Takahashi, K., Sato, Y., Yamamura, M., Nakada, S., Tamano, Y., Sasaki, M., & Harada, K. (n.d.). Notch-Hes1 signaling activation in Caroli disease and polycystic liver disease. Pathology International, n/a(n/a). https://doi.org/10.1111/pin.13130 Cite