Scientists describe the role of the host innate and adaptive immune responses as triggers of allogeneic graft rejection. They discuss how the immune response is determined by the cellular therapy.
[Communications Biology]
6445212 VUE5UWQF items 1 apa 0 default asc 1 163909 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-6366805f5025daaee630f048064fc381%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22VUE5UWQF%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Petrus-Reurer%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-25%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EPetrus-Reurer%2C%20S.%2C%20Romano%2C%20M.%2C%20Howlett%2C%20S.%2C%20Jones%2C%20J.%20L.%2C%20Lombardi%2C%20G.%2C%20%26amp%3B%20Saeb-Parsy%2C%20K.%20%282021%29.%20Immunological%20considerations%20and%20challenges%20for%20regenerative%20cellular%20therapies.%20%3Ci%3ECommunications%20Biology%3C%5C%2Fi%3E%2C%20%3Ci%3E4%3C%5C%2Fi%3E%281%29%2C%201%26%23x2013%3B16.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs42003-021-02237-4%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs42003-021-02237-4%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DVUE5UWQF%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Immunological%20considerations%20and%20challenges%20for%20regenerative%20cellular%20therapies%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandra%22%2C%22lastName%22%3A%22Petrus-Reurer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%22%2C%22lastName%22%3A%22Romano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Howlett%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joanne%20Louise%22%2C%22lastName%22%3A%22Jones%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Giovanna%22%2C%22lastName%22%3A%22Lombardi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kourosh%22%2C%22lastName%22%3A%22Saeb-Parsy%22%7D%5D%2C%22abstractNote%22%3A%22The%20central%20goal%20of%20regenerative%20medicine%20is%20to%20replace%20damaged%20or%20diseased%20tissue%20with%20cells%20that%20integrate%20and%20function%20optimally.%20The%20capacity%20of%20pluripotent%20stem%20cells%20to%20produce%20unlimited%20numbers%20of%20differentiated%20cells%20is%20of%20considerable%20therapeutic%20interest%2C%20with%20several%20clinical%20trials%20underway.%20However%2C%20the%20host%20immune%20response%20represents%20an%20important%20barrier%20to%20clinical%20translation.%20Here%20we%20describe%20the%20role%20of%20the%20host%20innate%20and%20adaptive%20immune%20responses%20as%20triggers%20of%20allogeneic%20graft%20rejection.%20We%20discuss%20how%20the%20immune%20response%20is%20determined%20by%20the%20cellular%20therapy.%20Additionally%2C%20we%20describe%20the%20range%20of%20available%20in%20vitro%20and%20in%20vivo%20experimental%20approaches%20to%20examine%20the%20immunogenicity%20of%20cellular%20therapies%2C%20and%20finally%20we%20review%20potential%20strategies%20to%20ameliorate%20immune%20rejection.%20In%20conclusion%2C%20we%20advocate%20establishment%20of%20platforms%20that%20bring%20together%20the%20multidisciplinary%20expertise%20and%20infrastructure%20necessary%20to%20comprehensively%20investigate%20the%20immunogenicity%20of%20cellular%20therapies%20to%20ensure%20their%20clinical%20safety%20and%20efficacy.%22%2C%22date%22%3A%222021-06-25%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs42003-021-02237-4%22%2C%22ISSN%22%3A%222399-3642%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs42003-021-02237-4%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-06-25T16%3A29%3A52Z%22%7D%7D%5D%7D
Petrus-Reurer, S., Romano, M., Howlett, S., Jones, J. L., Lombardi, G., & Saeb-Parsy, K. (2021). Immunological considerations and challenges for regenerative cellular therapies. Communications Biology, 4(1), 1–16. https://doi.org/10.1038/s42003-021-02237-4 Cite