The Novel Indomethacin Derivative CZ-212-3 Exerts Antitumor Effects on Castration-Resistant Prostate Cancer by Degrading Androgen Receptor and Its Variants

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Upon employing CCK-8 cell viability assays and colony formation assays, we found that these derivatives had high efficacy against CRPC tumor growth in vitro.
[Acta Pharmacologica Sinica]
Abstract