Short-Term Preclinical Application of Functional Human Induced Pluripotent Stem Cell-Derived Airway Epithelial Patches

Airway epithelial patches were engineered by differentiating human iPSC-derived airway progenitors into physiological proportions of ciliated and goblet cells on a silk fibroin–collagen vitrigel membrane composite biomaterial for transplantation in porcine tracheal defects ex vivo and in vivo.