Aging-Induced Impaired Endothelial Wall Shear Stress Mechanosensing Causes Arterial Remodeling via JAM-A/F11R Shedding by ADAM17

The authors determined the novel role for a disintegrin and metalloproteinase 17 in impaired wall shear stress mechanosensing, which was hypothesized to contribute to aging-associated abnormal vascular remodeling.