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[Proceedings of the National Academy of Sciences of the United States of America] Multipronged data on a complementary pair of murine metabolic-dysfunction-associated steatohepatitis (MASH) models and published single-cell RNA-sequencing datasets from MASH patients revealed a critical protective role for Foxp3+CD4+ Tregs in MASH.

[Nature Communications] Scientists assessed a Vδ1 + γδ T cell-based adoptive cell therapy, named Delta One T cells, to treat cytomegalovirus infection in high-risk transplant recipients.

[Cellares (Business Wire, Inc.)] Cellares and the University of Wisconsin School of Medicine and Public Health announced an expansion of their partnership to support clinical production and regulatory advancement of the university’s CRISPR-edited GD2 CAR-T investigational therapy for pediatric and adult solid tumors.

[Nature Biotechnology] The authors review the clinical progress of engineered cellular immunotherapies for autoimmunity, focusing on how antigenic target, engineered cell type, CAR design, and treatment regimens affect the therapeutic efficacy and safety of these treatments.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists engineered CD4+ T cells with CARs targeting fibrillar forms of aggregated amyloid-β.

[Gyala Therapeutics (PR Newswire)] Gyala Therapeutics announced the initiation of a Phase I/IIa clinical trial of GYA01 following authorization from the Spanish Agency of Medicines and Medical Devices (AEMPS).

[Biomarker Research] Researchers developed FuNVCAR, a T cell-targeted fusogenic nanovesicle system that delivers preformed αCD19 CAR proteins to T cells via membrane fusion.

[Nature Communications] Scientists engineered T cells that either constitutively over-express TCF1, or conditionally over-express TCF1 following differentiation of the cells into a CX3CR1+ intermediate-exhausted state.

[Nature Communications] The authors generated DKK1-A2 CAR-T cells that specifically and effectively lyse HLA-A2- and DKK1-expressing tumor cells but not blood or bone marrow cells from HLA-A2+ healthy donors.

[Blood Cancer Discovery] Knockout studies revealed that endogenous CD28 on 4-1BB co-stimulated CAR T cells prolonged in vivo activity, reprogrammed mitochondrial metabolism to maintain redox balance, and stimulated proliferation and release of tumor-model specific inflammatory cytokines in the tumor microenvironment.

[Journal of Clinical Investigation] Scientists observed increased frequencies of CD16-expressing classical monocytes in patients with acute COVID-19, and murine SARS-CoV-2 infection recapitulated this phenotype.

[Science Advances] Researchers contrasted varicella zoster virus antigen–specific memory T cell responses in adults vaccinated at young or older age with a live-attenuated vaccine conferring durable protection only when given at young age or with an adjuvanted component vaccine eliciting long-lasting immunity in older adults.