High-Sucrose Diets Contribute to Brain Angiopathy with Impaired Glucose Uptake and Psychosis-Related Higher Brain Dysfunctions in Mice

The authors demonstrated that a high-sucrose diet during adolescence induced psychosis-related behavioral endophenotypes, including hyperactivity, poor working memory, impaired sensory gating, and disrupted interneuron function in mice deficient for glyoxalase-1, an enzyme involved in detoxification of sucrose metabolites.