HMGA1 Stimulates MYH9-Dependent Ubiquitination of GSK-3β via PI3K/Akt/c-Jun Signaling to Promote Malignant Progression and Chemoresistance in Gliomas

Investigators revealed that HMGA1 and myosin heavy chain 9 (MYH9) were upregulated in gliomas and their expression correlated with WHO grade, and HMGA1 promoted the acquisition of malignant phenotypes and chemoresistance of glioma cells by regulating the expression of MYH9 through c-Jun-mediated transcription.