SPI1-Induced Downregulation of Fto Expression Promotes Glioblastoma Progression by Regulating Pri-miR-10a Processing in an m⁶A-Dependent Manner

Scientists found that decreased function of fat mass and obesity-associated protein (FTO) expression in clinical specimens correlated with higher glioma grades and poorer clinical outcomes. Functionally, FTO inhibited growth and invasion in glioblatoma cells in vitro and in vivo.