PET-Based Radiogenomics Supports mTOR Pathway Targeting for Hepatocellular Carcinoma

High 2[18F]fluoro-2-deoxy-d-glucose (FDG) avidity conferred worse recurrence-free survival after HCC resection. Whole transcriptome analysis revealed upregulation of mTOR pathway signals in the FDG-avid tumors, together with higher abundance of associated mutations.